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Nicotinamide N-methyltransferase (NNMT), an enzyme involved in fat synthesis and energy metabolism, is inhibited by 5-Amino-1MQ
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Researchers observed that ERRα activation by SLU-PP-332 increases transcription of OXPHOS genes (Complexes I-V), fatty acid oxidation enzymes (CPT1, MCAD), and mitochondrial biogenesis factors (TFAM, NRF1)
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