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The following groups of people are at a greater risk of developing a vitamin B12 deficiency: Vegans or vegetarians People 75+ years Having a digestive system disorder like Crohn’s or celiac disease Drinking excessive amounts of alcohol Having Sjögren’s syndrome Taking certain medications like oral birth control or metformin Common symptoms of a vitamin deficiency include fatigue, numbness, poor balance, memory loss, and breathlessness

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Nies and Keppler (2007) present evidence that ABCC2 is the major transporter for the elimination of glutathione S -conjugate, glucuronic acid conjugate and sulfate conjugate of various toxins and carcinogens from hepatocytes into the bile, from kidney proximal tubule cells into urine, and from intestinal epithelial cells into the intestinal lumen