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Previous reports using co-immunoprecipitation assays showed that N-terminal domain of ICP34.5 binds directly to Beclin-1 autophagy protein and interferes with autophagosome biogenesis (Orvedahl et al., 2007)
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82 – 85 This suggests that the induction of erastin is a specific anti-cancer pathway, only acting on cancer cells, and protecting normal cells from ferroptosis
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