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The most proximal is the N-terminal death domain (DD), which is followed by the proline/serine/threonine rich domain (ProST), a C-terminal kinase domain (KD) (in IRAK1 and IRAK4), or pseudo-kinase domain (in IRAK2 and IRAK3), and a C-terminal domain required for the recruitment and activation of the downstream effector TNF receptor-associated factor 6 (TRAF6)
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[117] The following table summarizes the applicant's assertions regarding the substantial clinical improvement criterion
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