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Effects of kratom on other drug transporters recognized to be of clinical importance by the FDA, including organic anion transporting polypeptides (OATPs), organic anion transporters (OATs), organic cation transporters (OCTs), multidrug resistance proteins (MRPs), and bile salt export pump (BSEP), are lacking ( Kratom extracts and alkaloids, including mitragynine, have been reported to activate the pregnane X receptor in HepG2 cells (EC 50 ∼5 μ g/ml and 1–5 μ M, respectively) (Manda et al., 2017
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