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Animal experimental evidence Osteoclast precursor (RAW264.7) experiment: AOD 9604 significantly inhibited RANKL induced osteoclast formation, reduced the number of TRAP positive multinucleated cells, and decreased bone resorption pit formation
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Furin is generally membrane bound, but an active isoform has been described that can be secreted, potentially facilitating cleavage of the SARS-CoV-2 spike protein in the cellular neighbourhood
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