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Reconstitution and administration for both peptides Both cagrilintide and retatrutide are typically supplied as lyophilized (freeze-dried) powders that require reconstitution with bacteriostatic water before use
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217,218 Furthermore, ligand-dependent and ligand-independent activation modes allow Hedgehog signaling to support CSC maintenance via paracrine or autocrine mechanisms, particularly in Hedgehog-driven malignancies such as basal cell carcinoma and medulloblastoma
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