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In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 μg vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)
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These analyses reinforce that the cyst/tumor cell population likely derives from IC-A rather than principal cells (PC), supporting the model that cysts, cystadenomas, and chromophobe carcinomas originate from a common IC-A lineage
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