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When patients experience numbness whilst taking Mounjaro, alternative explanations should be thoroughly explored: Pre-existing diabetic neuropathy – many patients prescribed Mounjaro have longstanding type 2 diabetes, a condition frequently complicated by peripheral nerve damage Rapid metabolic changes – significant improvements in glycaemic control may temporarily affect nerve function Nutritional factors – reduced food intake due to gastrointestinal symptoms or appetite suppression might affect nutrient intake Concurrent medications – polypharmacy in diabetes management may include drugs with neurological side effects, particularly metformin which can reduce vitamin B12 levels with long-term use (MHRA Drug Safety Update) Whilst individual case reports exist in patient forums and anecdotal accounts, these do not constitute clinical evidence of causation