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The placebo effect can be observed in this study as 14 patients in the control arm had a greater than 50% reduction of pain at 60 minutes with administration of 5 mL 0.9% sodium chloride alone Akathisia was only experienced in 13.8% of haloperidol treated patients (which was not statistically significant) which is in line with prior reports of a low side effect profile with 2mg of haloperidol The incidence of akathisia was significantly lower in this trial compared with previous reports, leading the authors to suggest the pre-treatment with diphenhydramine is unnecessary when using haloperidol at this 2.5mg dose

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