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It further maintains central nervous system homeostasis by normalizing disrupted neurotransmitter signaling involving dopamine, serotonin, and gamma-aminobutyric acid (GABA), essential for stabilizing synaptic function and ensuring neuromuscular coordination after injury or toxin exposure [43, 45]
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When stimulated, these sensors initiate activation of complex pathways that include induction of C/EBP homologous protein (CHOP), splicing of mRNA for X-box-binding protein 1 (XBP1), called XBP1s, and phosphorylation of eukaryotic initiation factor 2α (eIF2α) [160, 161]
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