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Amino acids regulate mTORC1 lysosomal localisation and subsequently activate mTORC1 through Rag GTPase-dependent and Rag GTPase-independent pathways (Reference Liu and Sabatini80βReference Jewell, Kim and Russell82)
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An extension to the elevated HVA is the lack of production of GSH - as mentioned above and an alteration in the GSH:GSSG ratio
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