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In the U.S., the cost of treating diabetic neuropathy alone is nearly $11 billion every year (Foundation for Peripheral Neuropathy, 2025)
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IM3829 (4‐[2‐Cyclohexylethoxy] aniline) decreases Nrf2 mRNA and protein levels, and combined treatment with radiation is able to significantly inhibit cancer cell survival, suggesting a promising radiosensitizer in lung cancer treatment.135 By screening a siRNA library that targets the majority of the druggable genome, a study found that Grassypeptolide A, an active peptide isolated from marine cyanobacteria contains actin, is able to attenuate Nrf2 activity.169 However, the cytotoxicity and bioactivity of these compounds are still unclear
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