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Image acquiring was carried out using a Plan-APO 100 × /1.4 NA oil objective with the following filter set: BP 450–488 nm, FT 495 nm, and BP 512–542 nm

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NOS contains three types include endothelial NOS (eNOS), which regulates blood vessel dilation and cardiovascular function, neuronal NOS (nNOS),which involved in neurotransmission and brain function and inducible NOS (iNOS) that produced during immune responses, helping to kill pathogens