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Additionally, in human post-mortem studies a downregulation of several antioxidant genes and an increase in protein oxidation have been observed in the hippocampus and prefrontal cortex of patients with BD 55,56
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Similar to the findings in a previous study on effects of methylation on strand separation of methylated DNA, hydroxymethylation also affects bubble formation during DNA stretching, which controls the propensity for strand separation
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