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Surgery remains appropriate for certain cases, and the decision should be individualized
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Consequently, iron chelators [68] (such as DFO and DFOM), ferrostatin-1 [69], POR inhibitors [34], and LPO inhibitors (e.g., liproxstatin-1) [70] can reduce the formation of PUFA-PE-OOH by attenuating the content of Fe 2+ in vivo or inhibiting the catalytic activity of ALOXs or POR, thereby preventing ferroptosis
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