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A significant advantage of GEMMs is that primary tumors which occur in such models are exposed to a functional immune system and a physiological tumor microenvironment, with subsequent BM occurring spontaneously [139]
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Cells were seeded in 96-well plates at cell density 10 4 /well, treated with HCH or BSO or in combination and incubated at 37°C in 5% (v/v) CO 2 for indicated times
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