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Serum marker trends will likely show improvement within a few weeks of initiating therapy, but subjective improvement in symptoms are more challenging to assess, and often patients are left with permanent impairments, especially in gait abnormalities
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Furthermore, each protein’s expression level was significantly and negatively correlated with the gastrocnemius pooled CSA (Spearman’s correlation, P 78%) of DEPs common to NNMTi treatment and exercise were regulated in the same direction, suggesting that many cellular responses were similar between the two interventions
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