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Treatment with SF reduced NF-кB pathway activation and decreased levels of cytokine gene expression and protein levels of MMP-9, TNF-α, IL-6, and IL-1β in the spinal cord lesions at 12 and 24 h after SCI [249,250,251]
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In lupus, NF-kB is constitutively activated in multiple immune cell types, driving the persistent inflammatory state that characterizes the disease
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