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Similarly, HLA-DR4 transgenic mice that lack the co-stimulatory molecule CD28, which greatly reduces the number of T reg cells, also develop persistent arthritis after spirochaetes have been killed 108
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The co-occurrence of GSH depletion and iron accumulation is mechanistically significant: under conditions of GSH deficiency, glutathione peroxidase 4 (GPX4) activity is compromised, impairing the enzymatic reduction of phospholipid hydroperoxides
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