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Since it contains cobalt in the centre of a corrin ring, those with cobalt allergies may experience allergic skin eruptions from methylcobalamin intake
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It tends to: Start within 1-3 weeks of initiating Zepbound or escalating dose Peak during weeks 2-6 Improve gradually as the body adapts to lower caloric intake and improved insulin sensitivity Resolve fully by week 12-16 at a stable dose for most patients Respond well to the sleep protocol below Persistent sleep disruption is less common but more concerning
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