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141,142 Recurrent somatic mutation of residues are mainly located at enzymatic active sites that bind to isocitrate, typically at R132 including R132H, R132L, R132S, R132C, and R132G in IDH1, and R140Q or R172K in IDH2
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Structural characterization of SERF2 reveals partial disorder Studying the detailed structure of ribonucleoprotein condensates is challenging due to their dynamic and heterogeneous nature 64 , and often the large size and complex multi-component composition of these condensates
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