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They are often prescribed to treat or prevent vitamin B12 deficiency, which can result from various conditions like pernicious anemia or gastrointestinal disorders that affect the absorption of nutrients

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You mentioned gut, and I think it’s probably worth noting that, you know, the largest concentration of diamine oxidase is in the lining of the gut, meaning if you have any digestive issues, gastrointestinal inflammation, you immediately lose that, you know, frontline histamine-metabolizing layer, which also then leaves you more vulnerable to reactions to dietary histamines, because it’s DAO that would normally take care of those for you