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As feedback regulation, S6K could inhibit mTORC1 pathway through phosphorylating and inhibiting insulin receptor (IRS)/PI3K/AKT signaling and thus benefit longevity processes
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Activated Smad2/3 then translocate into the nucleus, initiating transcriptional regulation of numerous fibrotic genes, triggering fibroblast phenotype transformation, promoting EMT, and significantly enhancing ECM accumulation (Peng et al., 2022
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