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In published preclinical research, BPC-157 has been administered at doses ranging from 6 to 50 micrograms per kilogram body weight in animal models, with most tissue-repair and gastric-protection protocols using 10 to 20 mcg/kg once or twice daily (PMID 21030672, PMID 32558293, PMID 38980576)
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The mechanism relevant to tendon healing centers on VEGF pathway modulation and nitric oxide system regulation, both of which support the angiogenic and inflammatory phases of tissue repair
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