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Eventually, this phenomenon became known as the “Jarisch-Herxheimer reaction.” Over the years, patient communities have adopted a shortened version of the full name, calling them “Herxheimer reactions,” which I’ll use moving forward, or “herxes.” The reaction tends to happen in people with spirochetal infections, such as Lyme disease, relapsing fever, and others, when they’re treated with antibiotics, according to a medical review in StatPearls