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Interestingly, the use of drugs targeting ACSL4, such as the antidiabetic class of compounds known as glitazones, was associated with a reduction in the incidence of PD in a retrospective cohort study [541], providing further support for ACSL4 as a potential therapeutic target of PD
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Inhibition of P-glycoprotein and gut wall metabolism, eg, by grapefruit juice, may be associated with substantially increased drug absorption
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