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Fibroblast growth factor 21 (FGF21) induced by APAP overdose also increases the abundance of Nrf2 in the liver through peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) expression [115]
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Nevertheless, the experimental design of this work do not allow to point out whether the effect of arsenic on ISGU was due to alterations in insulin signaling, or a defect in the differentiation of these cell lines
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