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This reaction is essentially a reversal of the thiolase (HADHB or ACAA2) catalyzed reaction of fatty acid β-oxidation but is in fact catalyzed by the mitochondrial enzyme acetoacetyl-CoA thiolase (encoded by the ACAT1 gene)
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Three hundred obese adults with a body mass index of 35 or higher took one of five oral doses of AOD-9604, or a placebo, once daily for twelve weeks, after a two week single blind placebo run-in
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