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Mounting evidence suggests that NAD + contributes to the pathogenesis of inflammation-related fatty liver diseases, including hepatocytes and macrophages, as well as other cell types (Guilliams and Scott 2022)
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TDO activity is chiefly governed by the amino acid's level itself, and therefore its biological action is usually steady and not influenced by inflammatory mediators.77 During conditions of inflammation and increased oxidative stress, IDO activation in the extrahepatic tissues shifts the metabolism of tryptophan away from the liver
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