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Tubular epithelial cells undergo β-catenin-driven EMT via Twist1/Zeb1 upregulation and excessive extracellular matrix (ECM) production (collagen I/IV, fibronectin), correlating with rapid eGFR decline in human biopsies (3.5-fold higher nuclear β-catenin in progressive DKD)

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Because higher meat intake may co-occur with other sleep-relevant exposures (e.g., alcohol intake and caffeinated sugar-sweetened beverages [SSBs], such as cola) and with more processed/fast-food dietary patterns, residual confounding and dietary co-patterning cannot be fully excluded [155]