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It stimulates fibroblast proliferation and modulates collagen, elastin, and glycosaminoglycan synthesis (Pickart & Margolina, PMID 29986520), and it upregulates matrix metalloproteinase-2 expression in fibroblast culture (Siméon et al., PMID 11045606)
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While ageing is one of the most common contributors, several other elements may accelerate cartilage wear
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