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HK2 overexpression is associated with aggressive breast cancer phenotypes, and its pharmacological inhibition using 2-deoxy-D-glucose (2-DG) enhances the efficacy of conventional chemotherapeutics like doxorubicin and paclitaxel (Patra et al., 2013), with clinical studies confirming 2-DG’s chemosensitizing potential (Raez et al., 2013)
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