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In contrast, during molecular dynamics simulations, the spatial orientation of Arbutin in the Arbutin_b conformation shows noticeable changes compared to its docked structure, which may be attributed to the limited space within the binuclear copper active site that constrains the positioning of the pyranosyl glucose moiety (Fig

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For further information, see PHE and Health Education England’s e-learning session All Our Health: Antimicrobial Resistance (portal.e-lfh.org.uk/ Component/Details/571263), PHE guidance Health matters: antimicrobial resistance (www.gov.uk/government/ publications/health-matters-antimicrobial-resistance), and the PHE campaigns Antibiotic Guardian (antibioticguardian.com/) and Keep Antibiotics Working (campaignresources.phe.gov