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Finally, they concluded that collagen-peptide downregulates inflammation responses by accelerating the CD4 + T cells’ growth toward Th1 and Treg cells, through enhancing IFN-γ-mediated STAT1 phosphorylation in pre-activated CD4 + T cells followed by Janus kinase (JAK)-STAT signaling, which is supposed to participate in reducing immune responses mediated by Th2 [56]
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