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doi: 10.1038/s41392-022-01229-y [DOI] [PMC free article] [PubMed] [Google Scholar] 19
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By binding to the IGF-1 receptor (IGF1R), IGF-1 initiates the phosphorylation of phosphatidylinositol 2-phosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which activates downstream signaling pathways involving AKT and the mammalian target of rapamycin (mTOR)
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