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Studies using proliferating melanocyte cultures showed that estrogen receptor alpha (ERα) complexes interact with melanocyte-specific transcription factors to regulate melanogenic genes, which leads to hyperpigmentation as seen in pigmentation disorders associated with elevated estrogen levels [50]
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In previous studies involving transgenic mice, we demonstrated that even a moderate elevation in IOP can result in altered vascular autoregulation and endothelial impairment in the retina, coupled with overexpression of NOX2 [418,419]
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