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Moisturizers The American Academy of Dermatology has called the use of unmedicated topical moisturizers “ an internationally accepted standard adjunctive therapeutic approach to the treatment of psoriasis .” In fact, in controlled trials of corticosteroid topical treatments, in which placebo is essentially an unmedicated moisturizer, placebo response rates of up to 47% have been found, suggesting moisturizers alone have a beneficial effect in psoriasis (Menter 2009)