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The critical role of interleukin-1 beta (IL-1 β ) is demonstrated by studies where intracerebroventricular administration of an IL-1 β receptor antagonist mitigates sevoflurane-induced cognitive deficits in rodents (20)
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194,195 mTORC2 also mediates Thr450 phosphorylation of AKT, which is independent of PI3K, occurs during AKT translation and contributes to AKT stability
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