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This would be further analyzed specifically with respect to the particular myocardial lesion and heart failure in the large syndrome commonly seen also with the endothelium damaging agent overdose, alcohol [40] and lithium [39], acute pancreatitis [37], and maintained intra-abdominal hypertension, grade III and IV [31], as well as in the described occlusion syndrome with major vessels occlusion, peripheral [19,24,29] or central [27]

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however, this example, combined with the others above, also highlights that activation or inhibition of these enzymes is beneficial in a context-dependent manner