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The main symptoms include: Extreme tiredness Lack of energy Red or sore tongue or mouth Pale skin Changes in mood Changes in movement and balance Feeling pins and needles in arms and feet Reasons for vitamin b12 deficiency Vitamin b12 deficiency is caused mainly by two reasons
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The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis
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