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Given the roles of molecular effectors, local protein degradation, cytoskeletal dynamics, and molecular motors in the specification of axons (de Anda et al., 2002), suggesting that molecular cues exist that control dendrite initiation separately from axon initiation and dysregulation of such mechanisms could have pathological consequences (Cox and Cachon-Gonzalez, Dendritic synapses In the hippocampus and cortex, the majority of excitatory synapses are formed on spines while inhibitory synapses are predominantly formed on the cell bodies and dendritic shafts
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