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We then discuss evidence that highly reactive free radical species, especially reactive oxygen species (ROS) generated in endometriosis patients damage intracellular structures and genomic material to adversely impact the structural integrity and viability of oocytes, sperm, and embryos, evaluate literature data that implicates oocyte and fetal aneuploidy as contributing factors for infertility caused by endometriosis, and we discuss therapeutic horizons for treatment of endometriosis patients with antioxidant therapies
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Therefore, we performed pharmacokinetic studies of BPC157 in beagle dogs following single IV administration at a dose of 6 μg/kg, single IM administration at doses of 6, 30, or 150 μg/kg, and repeated IM administration at a dose of 30 μg/kg for seven consecutive days
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