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SUMOylation of Lys1270 of VEGFR2 leads to its retention in the Golgi, reducing its expression on the cell surface and impairing VEGFR2 signaling
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Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity
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