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These features enable a “bystander effect”, allowing the elimination of neighboring tumor cells with low or heterogeneous antigen expression and broadening the clinical utility of ADCs [57]
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Together with gut microbes and the mucosal immune system, IECs constitute the first line of defense against luminal pathogens and antigens ( In contrast, pathogenic colonization disrupts commensal communities and adversely affects IEC structure and function ( Firmicutes ), reducing SCFA availability—a double blow to IEC homeostasis
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