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To complement the Jadad score, the Cochrane Risk of Bias Tool (RoB 2) (Sterne et al., 2019) was also used for RCTs to provide a domain-based qualitative evaluation, assessing risks related to selection, performance, detection, attrition, and reporting
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The two medications work through entirely different mechanisms — phentermine through central stimulant pathways, GLP-1s through appetite and metabolic signaling — which is precisely why combining them can restart progress when either alone has stalled
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