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Recently, low concentrations of betaine (which is transported through the blood–brain barrier by BGT1/SLC6A12) have also been shown to inhibit GAT1, the transporter’s activity being restored by increasing the concentrations of extracellular GABA or betaine itself [163]
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Additionally, reperfusion ischemia is associated with ATP depletion, elevated intracellular calcium levels [ 85 ] , increased production of ROS, and reduced activity of antioxidant enzymes such as SOD, CAT, and GP X [ 86 , 87 ]
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