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The cells treated with Sp showed slight enhancement in levels of GSH (~1.2 fold), together with minor alterations in GSSG levels, compared to untreated samples which exhibited higher GSSG content, thus indicating efficient recycling of GSSG to GSH (Fig
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We observed a consistent trend toward reduced metastasis in the brain, bone, and liver, suggesting that mitochondrial GSH contributes to metastatic colonization across multiple organs (Supplementary Fig
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