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Methylation of m6A RNAs, regulated by the enzyme methyltransferase-like 3 (METTL3) (183), has been linked to many CVDs
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Nonresponders showed sustained expression of T-cell checkpoint markers on CD4+ and CD8+ T cells, higher proportions of regulatory T cells over time, and findings described as suggestive of immune suppression and T-cell dysfunction, while relapse was associated with increased proportions of CD4+ and CD8+ T cells expressing CD39 and CD57 and reduced BCMA receptor density on bone marrow tumor plasma cells
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