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Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway
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Tissue-specific upregulation in the endothelium, vascular smooth muscle cells, and cardiomyocytes correlates with disease severity in conditions such as heart failure and atherosclerosis [5]
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